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BACKGROUND: Oral ulceration is one of the commonly reported oral mucosa lesions in Chronic Kidney Disease (CKD) patients and it is strongly associated with increased systemic inflammatory burden which worsen the underlying kidney diseases.
OBJECTIVE: This study was aimed at determining the relationship between oral ulcerations and blood urea concentration.
METHODS: This study was designed as a cross sectional study. Participants were randomly selected chronic kidney disease patients attending Renal clinic of Obafemi Awolowo University Teaching Hospitals between January 2019 to December, 2019. They were interviewed and examined. Oral mucosa was carefully examined for ulcers and other oral features. Blood samples were taken to determine blood urea concentration. Information was obtained using a structured questionnaire and stored in a passworded computer. Data analysis was done using STATA 14. Analysis of the blood urea concentration in both participants with and without oral ulceration was determined using student t-test and ANOVA as appropriate, p value set at <0.05.
RESULTS: A total of 151 participants, 108(71.5%) male and 43 (28.4%) females participated, their mean age was 38.6years +14.1. Twenty-nine (19.2%) patients had oral ulcerations. The ulcers were more frequent on the lower lips (17, 58.6%). Of all the patients with oral ulcers, 20 (69.0%) were recurrent, 24 (82.6%) presented in acute stage, 23 (79.3%) were painful and 22 (75.9%) were solitary ulcers. Blood Urea concentrations of patients with oral ulcerations were significantly higher than those without oral lesion p=0.001 likewise the blood urea concentration of patients with painful ulcers were significantly higher, p=0.001.
CONCLUSION: About one out of five CKD patients would develop oral ulcer. Participants with Oral ulcerations had significantly higher blood urea especially when the ulcers present as acute, multiple, painful and recurrent lesion.