CLEAR CELL AMELOBLASTIC CARCINOMA: A case report and review of the literature CLEAR CELL AMELOBLASTIC CARCINOMA

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E B Edetanlen
O F Omoregie
C B Ogboh

Abstract

OBJECTIVE: This is a report of clear cell ameloblastic carcinoma
with a dual histomorphologic feature of clear cell odontogenic
carcinoma (CCOC) and ameloblastic carcinoma (AC) coexisting in
a single lesion. To the best of our knowledge, this is the first
reported case of clear ameloblastic carcinoma (CCAC) among
Nigerians.
CASE REPORT: A 53-year old Nigerian woman presented with an
anterior jaw swelling of 7 months duration. The swelling was
associated with toothache and tooth mobility. Cervicofacial
Computed Tomography (CT) done revealed an expansile, noncorticated unilocular radiolucency with scalloped margins. A preoperative incisional biopsy of the lesion gave a diagnosis of clear
cell odontogenic carcinoma, which showed proliferation of sheets
of clear cells and a covering hyperplastic para-keratinized
squamous epithelium. The patient had a total surgical excision of
the tumour under general endotracheal anaesthesia. A definitive
diagnosis of clear cell ameloblastic carcinoma was made from
histologic examination of the post-surgical specimen which showed
a biphasic lesion consisting of odontogenic epithelium with foci of
crowded outer ameloblast-like cells and inner stellate cells with foci
of hyperchromatic, vacuolated nuclei, spindle cells, clear cell
change, squamous metaplasia, keratin peals, necrosis and mitoses.
The stroma consists of loose fibrovascular connective tissue and
there was a covering hyperplastic para-keratinized squamous
epithelium. No radiotherapy or chemotherapy was performed. The
patient was followed up for 18 months without evidence of
recurrence or metastasis to distant sites.
CONCLUSION: This study reports a rare case of odontogenic
carcinoma in a Nigerian female diagnosed as CCAC, which
presented histologically with biphasic component that mimics AC
and COCC but a biologically less aggressive lesion. The findings of
this study agree with previous reports which describe CCAC as a
unique entity.

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How to Cite
Edetanlen, E., Omoregie, O., & Ogboh, C. (2019). CLEAR CELL AMELOBLASTIC CARCINOMA: A case report and review of the literature. African Journal of Oral and Maxillofacial Pathology and Medicine, 5(1), 31 - 37. Retrieved from https://ajompm.com/index.php/ajmp/article/view/115
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