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OBJECTIVES: To discriminate between benign and malignant salivary gland tumours, using their Ki-67 immunoreactivity in a South-South Nigerian population.
METHODS: A descriptive and analytical study of 42 formalin fixed paraffin embedded (FFPE) tissue blocks of histologically diagnosed neoplastic salivary gland tumours. FFPE tissue block of 21 benign and 21 malignant tumours were sectioned and stained with Ki-67(MIB1) primary antibody, using the polymer horseradish peroxidase method. The Ki-67 labelling index (LI) of each tumour was assessed. The mean Ki-67 LI of the benign salivary gland tumours was compared with that of the malignant tumours.
RESULTS: There was a generally low reactivity of the salivary gland tumours to Ki 67 antibody, only 31.0% cases showed immunoreactivity for Ki-67 antibody, and the Ki-67 LI ranged from 0.5 to 7 % in both the benign and malignant tumours. The mean Ki-67 LI for the malignant lesions (3.9%) was higher than that of the
benign tumours (2.4%), but the difference was not statistically significant [p=0.280].
CONCLUSION: This study showed that Ki 67 antibody cannot reliably differentiate a benign from a malignant salivary gland tumour, although the malignant lesions had a higher Ki 67 LI